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HT modulates cortical and hippocampal pyramidal cell
2024-10-31
5-HT modulates cortical and hippocampal pyramidal cell function in a very complex manner, since most 5-HT receptor subtypes (excitatory as well as inhibitory) are expressed on pyramidal Sivelestat as well as GABAergic interneurons that exert inhibitory control over pyramidal cells (Leiser et al., 20
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To assess relative metabolic activity and
2024-10-31
To assess relative metabolic activity and proliferation of Alrestatin attached to various substrates we used the MTT assay [29], [30]. In order to compare the metabolic activity of cells under the various conditions irrespective of the number or viability of the cells, we performed a PicoGreen DNA
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br Materials and methods br Results br Discussion Very few
2024-10-31
Materials and methods Results Discussion Very few ARF inhibitors have been developed to study the key functions these small GTP-binding proteins play in pathophysiology. The natural compound Brefeldin A (BFA) has exhibited drastic effects in cells such as collapse of the Golgi because of it
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br Discussion Myopathic EMG changes are
2024-10-31
Discussion Myopathic EMG changes are frequently detected in patients with MuSK MG, unlike in AChR MG patients [10]. However, these EMG changes are not always accompanied by myopathic histopathological findings. It has been shown that mitochondrial abnormalities seem to be more prominent in MuSK M
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130 ml mg It has been reported that leukotrienes and their r
2024-10-31
It has been reported that leukotrienes and their receptors, e.g. the cysteinyl leukotriene receptor 1 (CysLT1) may promote 130 ml mg injury (Ding et al., 2007) and that increased 5-LOX expression and activity lead to production of brain-toxic molecules (Khan et al., 2010). However, differential eff
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It has been suggested that the suppression of
2024-10-31
It has been suggested that the suppression of 5-LOX could promote apoptotic signaling pathways in cancers [6]. However, the role of 5-LOX in modulating apoptotic factors and neutrophil activation during ANP has not yet been evaluated. In this study, we aimed to evaluate the expression of 5-LOX in pa
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Based on the observation that antipsychotic
2024-10-31
Based on the observation that antipsychotic drugs increase 5-HT1A–D2 heteromerization level (Łukasiewicz et al., 2016), we set out to compare the effect of paroxetine to that of risperidone. Paroxetine, a potent SSRI, is very effective in the treatment of depression and anxiety disorders, e.g., gene
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Phospholipases cleave membrane phospholipids from inflammato
2024-10-31
Phospholipases cleave membrane phospholipids from inflammatory cells, activated platelets, erythrocytes, adipocytes and cancer Fidaxomicin (Aoki et al., 2008, Neidlinger et al., 2006). Several reports have analysed the role of LPA and its receptors in the pathogenesis of RA. Zhao et al. reported t
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Based on the extracellular domain structures we can infer th
2024-10-31
Based on the extracellular domain structures, we can infer that the dimer arrangement of GABAB receptor will undergo substantial changes upon receptor activation (Geng et al., 2013). First, agonist-stimulated closure of GABAB1 VFT would cause an upward rotation of its LB2 domain, coupled with an inw
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The mitogen activated protein kinase MAPK
2024-10-30
The mitogen-activated protein kinase (MAPK) plays an important role in a variety of cell processes by controlling transcriptional or translational regulation [14]. There are three major MAPK family members that have been well characterized: extracellular signal-regulated kinase (ERK), c-Jun N-termin
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Autophagy and apoptosis have a very complex relationship and
2024-10-30
Autophagy and apoptosis have a very complex relationship, and the precise mechanism remains to be determined. At present, a large amount of research has confirmed that autophagy can protect the cell from apoptosis in special conditions such as nutrient deficiency or growth factors deprivation; the e
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br Introduction Humans have consumed mushrooms for centuries
2024-10-30
Introduction Humans have consumed mushrooms for centuries because of their high nutrient content and low lipid content, as well as their excellent flavor and texture [1]. Edible mushrooms possess notable medicinal properties and bioactivities, including antitumor, antiviral, antidiabetic, and ant
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The sequential behavioral approach used in the present study
2024-10-30
The sequential behavioral approach used in the present study reinforced the involvement of the BDNF/TRKB system in the effect of losartan. In mice with dampened BDNF expression, losartan was no longer able to exert antidepressant-like effects. Similar to what was observed after losartan treatment, t
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Accumulating evidence indicates that experience
2024-10-30
Accumulating evidence indicates that experience-dependent alterations in glutamate transmission in the NAc, such as those produced by repeated exposure to cocaine, involve alterations in postsynaptic signaling mediated by AMPA-type receptors (Pierce and Wolf, 2013, Wolf and Ferrario, 2010). In the N
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There are human genes in the
2024-10-30
There are 12 human genes in the SLC5A family, and 6 of these are expressed in human heart (Table 2). Little is known about SGLT proteins in the heart. Zhou et al. [56] reported the presence of SGLT1 mRNA in the human heart. Researchers have found that levels of SGLT1 mRNA in heart are approximately
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