• We became interested in the potential role of

  2018-10-20

  

  We became interested in the potential role of ADF genes and calculating molarity dynamics during osteoblast (OB) differentiation of hMSCs for several reasons. First, actin and microtubules are abundant in osteoblasts (Aubin et al., 1983; Arena et al., 1991). During OB differentiation, cell morpholog

• Recent research suggests that NSCs tropism

  2018-10-20

  

  Recent research suggests that NSCs\' tropism towards neoplastic areas is driven by chemoattractants produced at the tumor site. The intratumoral hypoxic microenvironment activates SDF-1/CXCR4 and VEGF/VEGFR signaling pathways, which may act as downstream effectors to increase NSC tropism (Aboody et

• The following are the supplementary data related

  2018-10-20

  

  The following are the supplementary data related to this article. Author contribution Acknowledgment We thank Dr. Donald Vander Griend for providing CD133 cDNA, Dr. Oh-Joon Kwon and Ms. Li Zhang for technical help, the technical support by the Cytometry and Cell Sorting Core at Baylor College

• Recently human umbilical cord hUC has been

  2018-10-20

  

  Recently, human umbilical cord (hUC) has been investigated as a source of rora with stem/progenitor cell properties. hUC is a desirable source of stem/progenitor cells as it is routinely discarded after delivery, collection is non-invasive and an abundant number of cells are present in cord tissue (

• A microsatellite PCR profile has been

  2018-10-20

  

  A microsatellite PCR profile has been obtained for the cell line, and HLA Class I and II typing is available (Table 1). Blood group genotyping gave the blood group O1O1, expected to give rise to blood group O+ (Table 1). The cell line is free from mycoplasma contamination as determined by RT-qPCR.

• Embryonic stem cells ESCs are widely

  2018-10-20

  

  Embryonic stem myeloperoxidase (ESCs) are widely used to study early differentiation processes (Posfai et al., 2014). They also hold promise for therapeutic approaches in the field of regenerative medicine (Dressel, 2011; Dressel et al., 2008; Song et al., 2015; Tang and Drukker, 2011). Yet, immune

• br Acknowledgments br Introduction Expression of

  2018-10-20

  

  Acknowledgments Introduction Expression of a defined set of transcription factors (OCT4, SOX2, KLF4, and c-MYC) reprograms human somatic cells to a pluripotent state, generating induced pluripotent stem cells (iPSCs) (Park et al., 2008b; Takahashi et al., 2007; Yu et al., 2007). iPSCs are simi

• In conclusion we expect that this VP

  2018-10-20

  

  In conclusion, we expect that this VP64dCas9-BFPVP64 platform, which is significantly more potent than previous versions, will encourage the adoption of CRISRP/Cas9-based TF technology to achieve multiplexed gene activation for reprogramming as well as nonreprogramming applications in basic science,

• The activity of CXCL through CXCR receptor has been

  2018-10-20

  

  The activity of CXCL12(5-67) through CXCR3 receptor has been shown before (Denoyer et al., 2012; Zhu et al., 2009). Here we aimed to confirm this finding using CXCL9, a natural ligand of CXCR3. NSCs pre-treated with CXCL9 were not susceptible to the CXCL12(5-67) apoptotic effects. The effect of CXCL

• In conclusion the MC approach

  2018-10-20

  

  In conclusion, the MC approach described in this study provides a platform to generate a population of human PAX7+ myogenic progenitors from PS adenosine deaminase that can be terminally differentiated into MHC+ myocytes in vitro that is equivalent to iPAX7 cells. However, further development of th

• The neurogenic to gliogenic transition of NSPCs

  2018-10-20

  

  The neurogenic-to-gliogenic transition of NSPCs is probably governed by a multi-layered system. The epigenetic status of astrocyte-specific (Takizawa et al., 2001) and neurogenic genes changes during development (Hirabayashi et al., 2009; Kishi et al., 2012; Pereira et al., 2010), critically determi

• It is often pointed out

  2018-10-20

  

  It is often pointed out that tumor oxytocin receptor can escape immune cells by changing their antigenicity through the modification of targeted peptide sequences or reduction of HLA-molecule expression (Schreiber et al., 2011). This is usually the case when immune therapies with antigen-specific mo

• qRT PCR showed that the expression

  2018-10-20

  

  qRT-PCR showed that the expression of the PRC2 core components Ezh2, Suz12, and Eed was not reduced upon Dicer deletion (Figure 2A). Similarly immunoblotting showed no reduction of EZH2, SUZ12, or JARID2 proteins or global H3K4me3 or H3K27me3 (Figure 2B). Cellular fractionation experiments confirmed

• hdac inhibitors Introduction The majority of induced pluripo

  2018-10-20

  

  Introduction The majority of induced pluripotent stem cells (iPSCs) are not fully reprogrammed (Chan et al., 2009; Lee et al., 2013; Mikkelsen et al., 2008). There is still minimal information on transition checkpoints necessary to induce full reprogramming. Pluripotent stem cells (PSCs) have funct

• Alzheimer s disease AD is the most common

  2018-10-20

  

  Alzheimer\'s disease (AD) is the most common neurodegenerative disorder. The pathological hallmarks of AD include extracellular amyloid plaques consisting mainly of Aβ42, and intracellular neurofibrillary tangles comprising mainly hyperphosphorylated tau (Serrano-Pozo et al., 2011). Previous studies

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