• Microsomal fractions of earthworm tissue were prepared as pe

  2020-07-31

  

  Microsomal fractions of earthworm tissue were prepared as per a previous study with modifications (Zhang et al., 2006). Briefly, the earthworm tissue samples transferred into cold 0.15 mol l−1 KCl solution and were cut into shreds. The remaining solid tissue homogenized for 30 min at 8000 r.min−1. T

• ZEA is reported to induce ROS associated cell

  2020-07-31

  

  ZEA is reported to induce ROS-associated cell death, both through induction of apoptosis and autophagy (Fan et al., 2017, Zheng et al., 2018a, Zheng et al., 2018b), but there is no evidence whether ERs are involved in this process. Thus, in this study, we evaluate whether ZEA might induce oxidative

• Nitric oxide NO is a well

  2020-07-31

  

  Nitric oxide (NO) is a well-characterized signaling molecule that mediates various physiological effects [11]. In addition to its physiological significance, NO influences the functional states of transcription factors and other signaling molecules and modulates gene expression. Multiple studies hav

• The intrinsic pathway on the

  2020-07-31

  

  The intrinsic pathway, on the other hand, is initiated by the activation of BH3-only proteins which are usually transcriptionally activated by apoptosis stimuli. But there is one exception: BID is activated (termed tBID) by caspase cleavage (by caspases-2 or -8/10) (Czabotar, Lessene, Strasser, & Ad

• The biochemical separation of exonuclease activity

  2020-07-31

  

  The biochemical separation of exonuclease activity from DNA-PK dependent endonuclease activity reported in this manuscript is consistent with genetic separation of Artemis enzymatic activity. Mutations in the protein which result in disruption of endonuclease activity have no effect on exonuclease a

• br Methods br Results br Discussion

  2020-07-31

  

  Methods Results Discussion The current study aimed to understand the influence of the COMT polymorphism and the neurogenetic architecture of hearing loss induced tinnitus. Our data identify that Met carriers in combination with severe hearing loss are a good predictor for the loudness of th

• It is noteworthy that although

  2020-07-30

  

  It is noteworthy that although the naphthoate analogues 5 and 6 proved to be less potent DNA alkylating agents our experiments indicate that these compounds interact with DNA. This suggests that the presence of a DNA-affinity moiety in the bis-3-chloropiperidine molecule can contribute to DNA recogn

• br Results br Discussion DDR mice develop

  2020-07-30

  

  Results Discussion DDR−/− mice develop a mild renal phenotype without renal failure and without severe proteinuria (Gross et al. 2004b). Their local defect of the GBM affected less than 2% of the total GBM-area only. Further, their mild renal phenotype showed up later in life (6 to 9months of

• The IL family is also named

  2020-07-30

  

  The IL-2 family is also named the γ-chain (γc) family because the receptors for these cytokines share γc (also known as IL-2Rγ and CD132), which consists of IL-2, IL-4, IL-5, IL-7, IL-9, IL-15 and IL-21 [21]. Both circulating IL-2 and aortic IL-2 receptor are reported to increase in type A AD when c

• Another breakthrough towards the understanding of the mechan

  2020-07-30

  

  Another breakthrough towards the understanding of the mechanisms responsible for stress-induced relapse to drug seeking behaviour is the evidence published by the group of Wise [34] in which they show that the activation of VTA CRF2 and not CRF1 receptors is responsible for stress-mediated relapse t

• The CRF receptor binding affinities for

  2020-07-30

  

  The CRF receptor binding affinities for the described compounds are shown in . Compounds were tested in a CRF receptor binding titration assay using rat frontal VU 591 hydrochloride homogenate, in which inhibition of specific binding of [I]Tyr-ovine CRF by our test compounds was measured to determi

• Cytarabine Albiglutide a glucagon like peptide agonist

  2020-07-30

  

  Albiglutide, a glucagon-like peptide-1 agonist (GLP-1 agonist) for the treatment of type 2 diabetes (marketed as Tanzeum and as Eperzan and the US and Europe, respectively), was one of the first HSA-peptide or protein fusion product to be approved for clinical use. Whereas the Cytarabine of pharmac

• br Introduction M http www

  2020-07-29

  

  Introduction Microorganisms play a vital role in the remediation and detoxification of the environment. They are able to metabolize chemical contaminants that can be completely degraded to end products such as CO2 and H2O, or transformed to compounds with lower solubility and toxicity. Exposure t

• According to previous research stress experiences have signi

  2020-07-29

  

  According to previous research, stress experiences have significant effects on the acquisition, expression, Compstatin and reinstatement of CPP induced by cocaine (Logrip et al., 2011, Lu et al., 2003, Sanchez and Sorg, 2001). Previous studies in our laboratory have shown that mice exposed to socia

• Acute lung injury ALI is

  2020-07-29

  

  Acute lung injury (ALI) is a life-threatening disease characterized by serious lung inflammation and increased capillary permeability. Isofraxidin (IF) 36, a Coumarin Fmoc-Thr(tBu)-OH isolated from the natural medicinal plants such as Sarcandra glabra and Acanthopanax senticosus, which have been re

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