• Our previous studies have demonstrated that the DDR

  2020-08-03

  

  Our previous studies have demonstrated that the DDR2 discoidin domain fully contains the binding site(s) for the fibrillar collagens I and II (Leitinger, 2003, Leitinger et al., 2004). The binding site for collagen I was mapped to three spatially adjacent surface loops within the DDR2 discoidin doma

• One of the most abundant natural flavonols

  2020-08-03

  

  One of the most abundant natural flavonols quercetin has previously been shown to potently inhibit CYP2E1 and CYP3A4 activity in vitro in different species including humans (Rastogi and Jana, 2014), pigs (Ekstrand et al., 2015), and rats (Zhou and Tang, 2005). Gender-related differences in the inter

• br Conflict of interest br Acknowledgement br

  2020-08-03

  

  Conflict of interest Acknowledgement Introduction Ligand-gated chloride channels (LGCCs) play a physiologically important role as neurotransmitter receptors that commonly mediate inhibitory signals in the nervous systems of animals [1,2]. These chloride channels, including γ-aminobutyric DC

• Coactivator binding induces substantial APC C conformational

  2020-08-03

  

  Coactivator binding induces substantial APC/C conformational changes that globally shift the platform and catalytic core into proximity of the substrate-binding module and increase the mobility of domains contributing to catalysis 21, 24 (Figures 2 A and 4 B). Most strikingly, repositioning of APC4

• A number of chemical strategies have been developed to

  2020-08-03

  

  A number of chemical strategies have been developed to design activatable optical imaging probes and have been summarized in several excellent reviews 11., 12., 13., 14., 15.. Fluorogenic enzyme substrates are one of the most explored activatable probe types for enzyme detection. These probes contai

• br The regulation of DNA PK activity

  2020-08-03

  

  The regulation of DNA-PK activity How DNA-PK is activated or deactivated in response to DNA damage and other cellular stress, is still relatively unknown [38]. Previous studies have shown that two serine/threonine protein phosphatase PP5 and PP6 are involved in DNA-PK activity modulation [39], [4

• During these processes meiotic recombination plays

  2020-08-03

  

  During these processes, meiotic recombination plays a critical role by physically associating homologs and ensures accurate chromosome segregation. In addition, meiotic recombination redistributes genetic material between homologs, resulting in haplotype diversity among progeny, impacting ecological

• br Introduction br Sphingolipid metabolism Sphingolipids

  2020-08-03

  

  Introduction Sphingolipid metabolism Sphingolipids, are fundamental constituents of all eukaryotic membranes and their metabolism is carried out by a broad array of anabolic and Dehydroandrographolide with ceramide as their hub (for a review, (Hannun and Obeid, 2018)). Ceramide can be formed

• An NDE of a predicted molecular mass of kDa has

  2020-08-03

  

  An NDE3 of a predicted molecular mass of ∼55kDa has been localized both in the mitochondria and in the cytosol of N. crassa and its sequence shows no typical features of a mitochondrial cleavable targeting sequence (Carneiro et al. 2007). This enzyme has been proven to be anchored in the inner mitoc

• Because the formation of chromosome axes is a prerequisite

  2020-07-31

  

  Because the formation of chromosome axes is a prerequisite for pairing, synapsis, and meiotic recombination, the HORMA domain 822 are ideally situated to monitor chromosomal events during meiotic prophase. This implies that the axis must undergo structural or biochemical changes during meiotic progr

• Microsomal fractions of earthworm tissue were prepared as pe

  2020-07-31

  

  Microsomal fractions of earthworm tissue were prepared as per a previous study with modifications (Zhang et al., 2006). Briefly, the earthworm tissue samples transferred into cold 0.15 mol l−1 KCl solution and were cut into shreds. The remaining solid tissue homogenized for 30 min at 8000 r.min−1. T

• ZEA is reported to induce ROS associated cell

  2020-07-31

  

  ZEA is reported to induce ROS-associated cell death, both through induction of apoptosis and autophagy (Fan et al., 2017, Zheng et al., 2018a, Zheng et al., 2018b), but there is no evidence whether ERs are involved in this process. Thus, in this study, we evaluate whether ZEA might induce oxidative

• Nitric oxide NO is a well

  2020-07-31

  

  Nitric oxide (NO) is a well-characterized signaling molecule that mediates various physiological effects [11]. In addition to its physiological significance, NO influences the functional states of transcription factors and other signaling molecules and modulates gene expression. Multiple studies hav

• The intrinsic pathway on the

  2020-07-31

  

  The intrinsic pathway, on the other hand, is initiated by the activation of BH3-only proteins which are usually transcriptionally activated by apoptosis stimuli. But there is one exception: BID is activated (termed tBID) by caspase cleavage (by caspases-2 or -8/10) (Czabotar, Lessene, Strasser, & Ad

• The biochemical separation of exonuclease activity

  2020-07-31

  

  The biochemical separation of exonuclease activity from DNA-PK dependent endonuclease activity reported in this manuscript is consistent with genetic separation of Artemis enzymatic activity. Mutations in the protein which result in disruption of endonuclease activity have no effect on exonuclease a

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