• Arsenic could cause apoptosis in both benign and malignant c

  2021-03-08

  

  Arsenic could cause apoptosis in both benign and malignant cells (Akao et al., 2000, Gupta et al., 2003, Namgung and Xia, 2001). However, at present, little is known about the consequences of arsenic-treated urothelial cells in autophagy and expression of its related proteins. In addition, the alter

• hif pathway br Deregulation of CDK Many neurotoxic or stress

  2021-03-08

  

  Deregulation of CDK5 Many neurotoxic or stress conditions like ischemic hif pathway damage, oxidative stress, mitochondrial dysfunctions, excitotoxicity, Aβ exposure lead to disruption of the tight regulation of Cdk5 (De Strooper et al., 2010). Calpain-mediated cleavage of p35 to p25 is activate

• In contrast to PEGylated proteins which tend to

  2021-03-08

  

  In contrast to PEGylated proteins which tend to have reduced pgds inhibitor in the body relative to their native counterparts, proteins conjugated to albumin tend to accumulate in certain locales in vivo. This means that albumin-based drug carrier systems have particular applications in the field o

• The instructive precedent for galectin phosphorylation is

  2021-03-08

  

  The instructive precedent for galectin phosphorylation is human galectin-3 (hGal-3). Its serine modification by protein kinase CK1 in the N-terminal tail is relevant for nuclear export during the course of apoptosis regulation and contact formation with the neural cell adhesion molecule L1 , , , . T

• Altered brain insulin signaling and CNS hypometabolism are a

  2021-03-08

  

  Altered ZM 447439 insulin signaling and CNS hypometabolism are also associated with pathogenesis of neurodegeneration. Insulin receptors are mostly located in the cerebral cortex, hippocampus, cerebellum, hypothalamus and olfactory bulb, possess an effective role in the regulation of central glucos

• In this study we investigated the

  2021-03-08

  

  In this study we investigated the role 17-phenyl tinor (pt)-PGE2 on endothelial barrier function and the underlying molecular mechanism in HMVEC-Ls as well as in a murine model of LPS-induced acute pulmonary inflammation. We found that 17-pt-PGE2 concentration-dependently enhanced endothelial barrie

• The GH family includes also xylanases which are not MeGlcA

  2021-03-08

  

  The GH30 family includes also xylanases which are not MeGlcA-dependent. Most of them are grouped to GH30_7 subfamily that includes XynIV from Trichoderma reesei showing exo- and endo-xylanase activity [11] and XYLD from Bispora sp. MEY-1 [12] having activity towards glucuronoxylan and arabinoxylan,

• Potential break through technology poised to overcome these

  2021-03-08

  

  Potential break-through technology poised to overcome these above-mentioned limitations is that of the “substrate mediated enzyme prodrug therapy”, SMEPT (Fig. 1). Learning from the previously established enzyme prodrug therapies (EPT) and specifically the antibody-directed EPT (ADEPT) [12], develop

• br Discussion The etiology of autoimmune

  2021-03-08

  

  Discussion The etiology of autoimmune diseases including psoriasis is intricate and a composite of environmental and biological factors. There are very limited studies available that report the association analysis of ACE I/D polymorphism with psoriasis risk. In the current study we report on ass

• Our finding that activating DDR

  2021-03-08

  

  Our finding that activating DDR2 variants are a cause of this disease suggested that the ABL inhibitor dasatinib, a leukemia drug that also inhibits DDR2, could be used for treatment of affected individuals.10, 11 To examine the effect of dasatinib on p.Leu610Pro- and p.Tyr740Cys-induced autophospho

• To assess whether the described cooperation between the EGFR

  2021-03-08

  

  To assess whether the described cooperation between the EGFR and FGFR receptors was relevant at the clinical level, we determined the effect on progression-free survival of FGFR1 expression in patients with adenocarcinoma who were receiving erlotinib or gefitinib. As we had observed EGFR-FGFR1 coope

• In the signaling cascade of

  2021-03-05

  

  In the signaling cascade of innate immunity, most of the receptor proteins, adaptor proteins, and kinases are modified by ubiquitination to activate and transduce the downstream signaling for efficient production of the IFN and proinflammatory cytokines to combat the pathogens. For example, the K-63

• br RING dimerization RING type domains

  2021-03-05

  

  RING dimerization RING-type domains are found in many different structural contexts. While many exist as single-chain Cy5 RNA (Fig. 3A), a notable feature of RING-type E3s is their tendency to form homodimers and heterodimers (Fig. 3C–F). Homodimeric RING-type E3s include cIAP, RNF4, BIRC7 (show

• br Acknowledgements This work was supported by National Natu

  2021-03-05

  

  Acknowledgements This work was supported by National Natural Science Foundation of China (No. 81400241). Introduction Fluoride, as a member of the halogen group of elements, naturally existed in water, soil, animals, and plants around the world (Singh et al., 2018), and it is present in trace

• br Acknowledgement br Introduction Human dihydroorotate dehy

  2021-03-05

  

  Acknowledgement Introduction Human dihydroorotate dehydrogenase (hDHODH), a flavin-dependent mitochondrial enzyme involved in de novo leukotriene receptor agonist biosynthesis, is a validated therapeutic target for the treatment of autoimmune diseases such as rheumatoid arthritis and cancer [1

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