• For hippocampal asymmetry two SNPs rs and

  2022-11-03

  

  For hippocampal asymmetry, two SNPs (rs1476679 and rs4147929) showed significant interaction with diagnosis. They have an inverse effect on asymmetry, which is consistent with their different roles as preventative or risk loci in AD. rs1476679 is intronic in the ZCWPW1 gene, is a histone modificatio

• A disfun o cognitiva p s operat ria uma

  2022-11-03

  

  A disfunção cognitiva pós‐operatória é uma síndrome perioperatória bem reconhecida, consequência da anestesia e cirurgia cuja causa exata permanece por esclarecer. De que forma Exemestane disfunção cognitiva pós‐operatória e a doença de Alzheimer podem estar ligadas permanece uma questão em estudo.

• KPT-335 Acetylcholinesterase AChE activity and expression le

  2022-11-03

  

  Acetylcholinesterase (AChE) activity and expression level can be down regulated by TCDD in neuronal cells [3], [6]. Thus AChE could be considered as a target of the neuronal toxicity of dioxin. AChE has several types of transcripts by alternative splicing in the 3′ region of primary transcripts [7],

• ACh induced changes in respiratory frequency could be of

  2022-11-03

  

  ACh-induced changes in respiratory frequency could be of interest. They may reveal an important mechanism of respiratory modulation at the caudal NTS level. ACh-induced increases in respiratory frequency within this region have been also reported by Furuya et al. (2014). Changes in respiratory timin

• The use of one or more of psychotropic medications

  2022-11-03

  

  The use of one or more of psychotropic medications and hypnotics was associated with a higher risk of falls in the current study. Previous studies have also shown that these medications increase the risk of falls in the geriatric population.25, 26, 27, 28, 29, 30, 31 Clinicians should weigh the risk

• br The Molecular Machinery of Autophagy and Regulation

  2022-11-03

  

  The Molecular Machinery of Autophagy and Regulation by Sphingolipids Sphingolipid-Mediated Autophagy in Cancer: Dr. Jekyll and Mr. Hyde Autophagy is an evolutionarily conserved stress response that typically promotes survival and antagonizes apoptosis. However, excessive autophagy was found to

• In the mammalian brain synapse formation is followed by a

  2022-11-03

  

  In the mammalian brain, synapse formation is followed by a period of synapse refinement, and autophagy has been shown to play an important role in this process. For example, Tang and colleagues found that autophagy is required for the developmental pruning of dendritic spines, and that this pruning

• In conclusion we report that the widely prescribed

  2022-11-03

  

  In conclusion, we report that the widely prescribed drug VPA exerts therapeutic effects on optic nerve demyelination and retinal degeneration in a mouse model of MS. Our findings raise an interesting possibility that combination therapy of VPA and ASK1 inhibition may be useful for treatment of autoi

• In order to further explore whether the cytoprotective effec

  2022-11-02

  

  In order to further explore whether the cytoprotective effect of isogarcinol against oxidative stress in H2O2-induced HepG2 kl compound name australia is a consequence of the breakdown of the endogenous antioxidant defence mechanism, we measured the LDH release, MDA levels, GSH levels and SOD activi

• Azithromycin br Materials and methods br Results br Discussi

  2022-11-01

  

  Materials and methods Results Discussion In this study, we have demonstrated that the adiponectin system (genes and proteins) is present in the porcine endometrium (epithelial glandular cells, luminal epithelial Azithromycin and stromal cells) and myometrium (longitudinal and circular musc

• Adenosine is an endogenous nucleoside that plays pivotal

  2022-11-01

  

  Adenosine is an endogenous nucleoside that plays pivotal roles in different physiological and pathophysiological processes by triggering specific cell-surface receptors both in the Aclacinomycin A and in the periphery. The adenosine receptors (ARs) are four different subtypes of G protein-coupled r

• There has been growing interest over

  2022-11-01

  

  There has been growing interest over computational methods to predict the biological activity by chemical structure, so as to decide whether it AAK1 dual inhibitor has objective qualities or not. In this contribution, the well-known method, which is called quantitative structure–activity relationshi

• br Animals Female Sprague Dawley SD

  2022-11-01

  

  Animals Female Sprague Dawley (SD) rats, aged 3 months with body weight between 180-210 g were housed in cages and acclimatized to standardized lab conditions (temperature 23 ± 2°C, humidity 50 ± 5% and 12 h light-dark cycles). The rats were fed with standard rodent food pellet (Harlan Diet, Ross

• In agreement with the role of ACLY

  2022-11-01

  

  In agreement with the role of ACLY in induced macrophage, we observe a drastically reduction of PGE2 levels when ACLY activity is inhibited. This is possible because PGE2 production requires arachidonic acid, which in turn is synthesized by elongation of dietary linoleic Cytarabine synthesis with a

• br Comparison to IWG In

  2022-10-31

  

  Comparison to IWG In addition to the NIA AA, the other group that has established diagnostic guidelines for AD that incorporate biomarkers is the IWG [64,74,75]. In the most recent formal IWG document, published in 2014 [75], the diagnosis of AD required the presence of cognitive symptoms plus an

16744 records 401/1117 page Previous Next First page 上5页 401402403404405 下5页 Last page