• Protein protein interaction networks are an important

  2023-01-30

  

  Protein–protein interaction networks are an important ingredient for the system-level understanding of cellular processes. Such networks can be used for filtering and assessing functional genomics data and for providing an instinctive platform for annotating structural, functional and evolutionary p

• thiotepa The LO has so far only been found in

  2023-01-30

  

  The 15-LO-1 has so far only been found in humans and rabbit reticulocytes [3], [20] and the rabbit 15-LO-1 protein demonstrate 81% identity to the human 15-LO-1. However, rabbit monocytes express an enzyme with mainly 12-LO activity [20], [21]. The high degree of sequence conservation between these

• br Results br Discussion Both ATM and ATR are key

  2023-01-30

  

  Results Discussion Both ATM and ATR are key regulators of the cellular response to DSBs, yet how exactly they function in concert is not well understood. Recent studies revealed that ATM is required for the resection of DSBs (Jazayeri et al., 2006, Myers and Cortez, 2006), a process necessary

• br Materials and methods br Results and

  2023-01-30

  

  Materials and methods Results and discussion During recent years, recombinant ASK1 has been obtained by expensive baculovirus-insect cell PHA-848125 systems [20], [27]. In the present study, we constructed recombinant ASK1 and expressed in active form at high level in E. coli. Human ASK1 cat

• Further important evidence for G protein signaling on early

  2023-01-30

  

  Further important evidence for G protein signaling on early endosomes has been subsequently obtained for the β2-adrenegic receptor using fluorescently-tagged conformation-sensitive nanobodies selectively recognizing the active receptor and Gs protein [43]. More recently, our group used a combinatio

• We also explored the possibility

  2023-01-30

  

  We also explored the possibility that this PKC-θ activating protein could operate on the auto-phosphorylation process of the kinase, a specific event accompanying PKC activation [32]. The heated PKC-θ immunoprecipitate from metaphasic cells was then added to PKC-θ isolated both from interphasic or m

• In addition to differential expression of

  2023-01-29

  

  In addition to differential expression of AR protein primarily in surgical specimens, genetic alterations involving the AR gene have been documented in human 2 hydroxypropyl β cyclodextrin cancer. Loss of heterozygosity at the AR locus was identified in all 3 informative cases of muscle-invasive bl

• Another class of AMPK regulator is peptidyl

  2023-01-29

  

  Another class of AMPK regulator is peptidyl-prolyl cis/trans isomerase (PPIase) NIMA-interacting 1 (Pin1), which binds to a number of proteins and regulates oncogenesis and metabolic diseases (Khanal et al., 2013; Zhou and Lu, 2016). Pin1 has been shown to bind to and inhibit AMPK; therefore, at lea

• How do increased levels of ammonia as

  2023-01-29

  

  How do increased levels of ammonia as observed in clinical HE constrain synaptic plasticity? Numerous studies have investigated the modulation of signal transduction pathways activated in LTP or LTD irrespective of being necessary or sufficient for changes in synaptic efficacy (Wen et al., 2013). Ye

• We recently identified a G A dependent epigenetic mechanism

  2023-01-29

  

  We recently identified a G9A-dependent epigenetic mechanism for transcriptional activation of the serine pathway in cancer cells (Ding et al., 2013). G9A, also known as EHMT2 and KMT1C, is a H3K9 methyltransferase that has a primary role in catalyzing H3K9me1 and H3K9me2 in euchromatin (Shinkai and

• Because activation of HT A receptor is capable of facilitati

  2023-01-29

  

  Because activation of 5-HT2A receptor is capable of facilitating dopamine cell activity and dopamine release (Bortolozzi et al., 2003), and this action of dopamine is known to mediate rat maternal behavior, especially maternal motivation (Afonso et al., 2007, Febo et al., 2010, Li and Fleming, 2003,

• Brain biopsy was performed from the white matter lesion arou

  2023-01-29

  

  Brain biopsy was performed from the white matter lesion around the posterior horn of the right lateral ventricle, and revealed inflammatory demyelination, such as myelin loss with relative preservation of axons, astrocytosis immnolabeled by TAK 165 against glial fibrillary acidic protein, infiltrat

• Macitentan The geometry of two three four and

  2023-01-29

  

  The geometry of two, three, four and five Macitentan neutral radical ACh molecule complexes with various electronic configurations, i.e. with various multiplicities equal to 1, 2 and 4 (for ACh trimer) were determined using DFT with the unrestricted B97d/SVP potential/basis set in Gaussian09 progra

• br Results br Discussion Dopamine

  2023-01-29

  

  Results Discussion Dopamine regulates behavioral responses to nicotine in Drosophila (Bainton et al., 2000), but neurochemical measurements of dopamine after nicotine stimulation had not been made. Here, we demonstrate for the first time that the stimulation of nAChRs causes dopamine release i

• br Materials and methods br Results The clinical characteris

  2023-01-29

  

  Materials and methods Results The clinical characteristics of the two selected groups are shown in Table 1. As shown in Table 1, the enzyme activity of ATX in CSF of MS patients (59.90±3.09nmol/min/ml±SEM) was significantly higher (p Discussion Numerous studies have so far shown that ATX tak

16744 records 377/1117 page Previous Next First page 上5页 376377378379380 下5页 Last page