• br Discussion Our second finding is that more than half

  2018-10-24

  

  Discussion Our second finding is that more than half (11 out of 18) of the environmental variable/AC associations examined were statistically different between rural and urban tracts. Four of these coefficients had the same direction but varied in effect size, but seven of these coefficients had

• In the current issue of

  2018-10-23

  

  In the current issue of E-BioMedicine, report intriguing data to show that very young asymptomatic SCA infants, whilst still producing very high total levels of HbF, demonstrate significant alterations in reticulocyte membrane protein expression, in association with reticulocytosis. The infants wit

• Biomarkers characteristics that can be objectively measured

  2018-10-23

  

  Biomarkers (characteristics that can be objectively measured as indicators of a pathogenic process) (Biomarkers Definitions Working Group, 2001) have the potential to contribute significantly in the battle against Mtb. The vast majority of Mtb-infected individuals remain healthy, suggesting that imm

• Disclosure br Integration of biomarkers into the majority of

  2018-10-23

  

  Disclosure Integration of biomarkers into the majority of drug development programs has led to a need for robust measurements and assay validation techniques for analyses of biological samples. The importance of solid methodologies for biomarker assessment is heightened by the fact that new drugs

• br Introduction Sepsis is a life

  2018-10-23

  

  Introduction Sepsis is a life-threatening syndrome commonly experienced by patients in critical care units. Sepsis syndrome poses a particular concern for people with prior health conditions, a phenomenon often referred as “second-hit” or “pre-conditioning” (Rocksen et al., 2004; Wang et al., 199

• Alterations in Ca TRP ORAI and RYR channels

  2018-10-23

  

  Alterations in Ca TRP, ORAI1 and RYR channels have been identified in cancer (Monteith et al., 2012; Ho et al., 2013; Love et al., 2012), and overexpression of CACNA1E are correlated with relapse in Wilms\' tumors (Natrajan et al., 2006), while CACNA2D1 plays a role in maintaining the properties of

• In this issue Uckun et al take the concept

  2018-10-23

  

  In this issue, Uckun et al. take the concept of SMaRT-mediated repair back to its roots and explore its use in the repair of an oncogenic defect, CD22ΔE12, in childhood B-precursor leukemia (BPL), the largest subset of B-lineage acute lymphoblastic leukemia (ALL) (). BPL hop over to this website ex

• To assess the effect of exercise on

  2018-10-23

  

  To assess the effect of exercise on body fat balance, the measurement of accumulated fat oxidation over 24h (24-h fat oxidation) is required. Persistent increases in fat oxidation during the post-exercise period require long-term calorimetry to evaluate the effect of exercise on body fat balance (Bi

• proteasome inhibitor Membrane disruption and ion dysregulati

  2018-10-23

  

  Membrane disruption and ion dysregulation are known components of Aβ toxicity. Aβ oligomers have also been shown to directly interact with membranes forming pores and disrupting the proper permeability of membranes (Kayed and Lasagna-Reeves, 2013). A distinct pore structured oligomer termed an annul

• Interestingly dataset analyses show that HK

  2018-10-23

  

  Interestingly, dataset analyses show that HK2 is highly expressed in CRPC compared to the primary prostate cancer. Our findings thus provide preclinical proof-of-concept that co-targeting Warburg effect with 2-DG and autophagy with CQ could be extended to effectively treat CRPC patients whose tumor

• In principle the screening for

  2018-10-23

  

  In principle, the screening for any type of drug resistance by searching for mutations in inhA, katG, and rpoB would allow to limit phenotypic DST to isolates with a equol identified in inhA, katG, and rpoB. Limiting phenotypic DST to isolates with a mutation identified in inhA, katG, or rpoB would

• The lack of such stratification may underlie the inconsisten

  2018-10-23

  

  The lack of such stratification may underlie the inconsistent data from trials of LMWH for PMPC (Martinelli et al., 2012; Rodger et al., 2014) due to inclusion of heterogeneous disease mechanisms rather than a focus on those associated with a procoagulant mechanism. These findings also suggest that

• br Conflicts of Interest br

  2018-10-23

  

  Conflicts of Interest Authors\' Contributions Funding Introduction Vaso-occlusive crisis (VOC), hallmark of sickle-cell disease (SCD), is the primary cause of Emergency-Department admissions and patients\' hospitalizations (Ballas and Lusardi, 2005). About 20% of all-age deaths in the Un

• Existing evidence indicates that both long and short term me

  2018-10-23

  

  Existing evidence indicates that trospium chloride both long- and short-term meditation practices change individuals\' affective processing and regulatory patterns (Chiesa et al., 2013). Theoretically, meditation emphasizes non-judgmental, open observations of thoughts, feelings, and stimuli from a

• Given the present data we

  2018-10-23

  

  Given the present data, we are not able to explain why the left auditory cftr was overactivated during 80-Hz ASSR stimulation. However, the left and right transverse temporal gyri and left planum temporale have some differential cytoarchitectonic features (Seldon, 1981; Hutsler and Gazzaniga, 1996)

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