• br Introduction Sepsis is a life

  2018-11-09

  

  Introduction Sepsis is a life-threatening syndrome commonly experienced by patients in critical care units. Sepsis syndrome poses a particular concern for people with prior health conditions, a phenomenon often referred as “second-hit” or “pre-conditioning” (Rocksen et al., 2004; Wang et al., 19

• am630 This study has highlighted the complexity of

  2018-11-09

  

  This study has highlighted the complexity of operationally defining compensation in neurodegenerative diseases such as HD. The previous literature in HD has thus far failed to address this issue, instead making assumptions of putative compensation based solely on increased activation or connectivity

• Due to their buoyancy circulating tumor cells CTCs are found

  2018-11-09

  

  Due to their buoyancy, circulating tumor Asunaprevir (CTCs) are found in the white blood cell fraction. CTCs have been investigated as a non-radiographic tool to monitor disease progression. The presence of CTCs suggests increased metastatic potential, and they have been investigated as a predicti

• Munc proteins are known to facilitate formation of trans

  2018-11-09

  

  Munc18 proteins are known to facilitate formation of trans-SNARE complexes that mediate SG fusion (Sudhof and Rothman, 2009). β-cells express all three Munc18 isoforms, Munc18a, b, and c (Oh et al., 2012; Lam et al., 2013; Zhu et al., 2015). We recently reported Munc18c/Syn-4 complex\'s role in insu

• br Material and methods br

  2018-11-08

  

  Material and methods Acknowledgment The authors would like to thank Mr. Chee Peng Ng (Institute of Molecular and Cell Biology, Singapore) for his help on the electron scanning microscope and Dr. William Birch (Institute of Materials Research and Engineering, Singapore) for his critical review

• Unspecific amplification of gene expression exploits informa

  2018-11-08

  

  Unspecific amplification of gene expression exploits information intrinsic to cells, initiating a self-organizing circuitry, where gene expression cascades propagate and interact, much like the propagation of microscopic fluctuations within a critical iron magnet. Unlike an iron magnet, the circuitr

• Introduction The stem cell niche is a unique microenvironmen

  2018-11-08

  

  Introduction The stem cell niche is a unique microenvironment that maintains long-term repopulation of a specific tissue by undergoing self-renewal of stem RGFP966 and by producing progenies of increasingly differentiated cells. A large amount of knowledge concerning the regulation of stem cell sel

• One group has recently identified bone marrow

  2018-11-08

  

  One group has recently identified bone marrow (BM)-residing very small embryonic-like stem cells (VSELs) in both human and mouse as a putative nonembryonic source for PSCs (Drukała et al., 2012; Kucia et al., 2006b; Wojakowski et al., 2009; Zuba-Surma et al., 2011). Mouse VSELs have been characteriz

• br Results br Discussion Here we have

  2018-11-08

  

  Results Discussion Here, we have shown that GATA4, MEF2C, TBX5, ESRRG, MESP1, MYOCD, and ZFPM2 together reprogram human fibroblasts toward a CM-like state. Human iCMs upregulated hundreds of CM-enriched genes, downregulated hundreds of fibroblast-enriched transcripts, and assembled sarcomeres.

• br Experimental Procedures br Author Contributions br

  2018-11-08

  

  Experimental Procedures Author Contributions Acknowledgments This work was supported in part by the Novel Bioengineering and Technological Approaches to Solve Two Major Health Problems in Taiwan sponsored by the Taiwan Ministry of Science and Technology Academic Excellence Program under gra

• In hematological malignancies cancer initiating cells have b

  2018-11-08

  

  In hematological malignancies, cancer-initiating BRD 7389 have been identified as a population potentially representing a key clinical target (Matsui et al., 2004; Dick and Lapidot, 2005; Gupta et al., 2009). This paradigm, now extended to some solid cancers, is based on the concept that a single

• Our results show that Exo has

  2018-11-08

  

  Our results show that Exo1 has a tissue-specific role in the maintenance of adult stem cell homeostasis: mice exhibited a significant defect in NSCs but not in HSCs. Exo1 deficiency resulted in a decrease in NSC proliferation, which was associated with increased expression of p21, whereas no signif

• br Material and methods br

  2018-11-08

  

  Material and methods Results Discussion The current study is the first report of the dynamic expression of ATF3 by ependymal spinal stem cells, as this protein was localized to the cytoplasm when such cells were quiescent, but was found in their nucleus when cells became activated. This pr

• In Raya et al found

  2018-11-08

  

  In 2009, Raya et al. found that somatic dihydrofolate reductase inhibitor from FA patients could only be reprogrammed after correction of the genetic defect, suggesting an important role for the FA pathway in establishing pluripotency (Raya et al., 2009). However, Tulpule et al. subsequently create

• Previous in vitro cell culture

  2018-11-08

  

  Previous in-vitro cell culture studies in microgravity have shown decreased osteoblast differentiation (Nabavi et al., 2011; Landis et al., 2000; Carmeliet et al., 1997), reduced osteoblast number (Hughes-Fulford and Lewis, 1996), and reduced osteoblast cell integrity (Nabavi et al., 2011). Furtherm

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